Glossary

Here are some words that you may hear. Understanding these words can help you understand your condition.

Add-on drug:

A medication taken along with another medication to treat the same problem.


AMPA receptor:

AMPA receptors help receive signals on nerve cells. When they receive too many signals, a seizure can happen.


Antiepileptic drug (AED):

A medication used to treat different types of seizures. Also may be called an anticonvulsant.


Aura:

A warning you may feel before a seizure. It is a strange feeling or sense that lets you know a seizure is about to happen. This is different for each person.


Complex partial seizure:

A seizure that starts in one part of the brain. Your awareness is affected.


Efficacy:

A measure of how a medication helps treat a condition or symptoms.


Epilepsy:

A group of related disorders defined by having seizures.


Focal seizure:

Another term that means “partial-onset seizure.”


Generalized seizure:

A seizure that starts in more than one part of your brain. Also called an idiopathic generalized seizure (IGE).


Grand mal seizure:

Another term that means "primary generalized tonic-clonic seizure (PGTC)."


Idiopathic generalized epilepsy:

A type of epilepsy that can cause many different types of seizures, including primary generalized tonic-clonic seizures.


Neuron:

A nerve cell. The brain has billions of neurons. They send signals to each other.


Partial-onset seizures:

A seizure that starts in one part of the brain. Also known as focal seizures.


Primary generalized tonic-clonic seizures:

This type of seizure starts in more than one place in the brain at the same time. During the seizure, muscles become stiff and then make jerking movements. Also known as grand mal seizures.


Seizure:

A change in signals in the brain. It affects how you feel, move, act, or think for a brief period of time.


Side effects:

Negative effect from medication or therapy.


Simple partial seizure:

A seizure that starts in one part of the brain. Your awareness is not affected.


Tonic-clonic seizure:

A seizure that causes muscles to become stiff and then make jerking movements.


Triggers:

Things that can cause a seizure to happen when it does. Two examples are flashing lights and stress.


Uncontrolled seizures:

When you are having seizures.


Indication and Important Safety Information

Indication

FYCOMPA (perampanel) is a prescription medicine used with other medicines to treat partial-onset seizures with or without secondarily generalized seizures and primary generalized tonic-clonic seizures in people with epilepsy who are 12 years of age and older.

Important Safety Information

FYCOMPA may cause: new or worse aggressive behavior, homicidal thoughts or threats, hostility, anger, anxiety, irritability, being suspicious or distrustful (believing things that are not true), and other unusual or extreme changes in behavior or mood. Before taking FYCOMPA, patients should tell their healthcare provider if they have or had mental problems, aggression or hostile behavior.

Patients, their caregivers, and families should monitor for these changes and call their healthcare provider right away if they have any new or worsening mental problems while taking FYCOMPA. The combination of alcohol and FYCOMPA significantly worsened mood and increased anger. Patients taking FYCOMPA should avoid the use of alcohol.

Antiepileptic drugs, including FYCOMPA, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients should call their healthcare providers right away if they have any of the following symptoms, especially if they are new, worse, or worrisome: thoughts about suicide or dying, thoughts of self-harm, attempt to commit suicide, new or worse depression, new or worse anxiety, feeling agitated or restless, panic attacks, trouble sleeping (insomnia), new or worse irritability, acting aggressive, being angry or violent, acting on dangerous impulses, an extreme increase in activity and talking (mania), and other unusual changes in behavior or mood.

Patients may have problems walking normally if they are unsteady because they feel dizzy. These symptoms may increase when their dose of FYCOMPA is increased. A patient’s risk of feeling dizzy and having problems walking normally may be higher if they are elderly. FYCOMPA may make patients feel sleepy or tired. Patients should not drive, operate heavy machinery, or do other dangerous activities until they know how FYCOMPA affects them. A patient’s risk of feeling sleepy and tired may be higher if they are elderly.

Taking FYCOMPA may increase a patient's chance of falling. These falls can cause serious injuries. A patient's risk of falling may be higher if they are elderly.

Patients must not stop FYCOMPA without first talking to their healthcare provider. Stopping FYCOMPA suddenly can cause serious problems and can cause patients to have seizures more often.

The most common side effects seen in patients receiving FYCOMPA were dizziness, sleepiness, headache, tiredness, irritability, falls, nausea, problems with muscle coordination, problems walking normally, vertigo, and weight gain. Tell your healthcare provider about any side effect that bothers you or does not go away.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking FYCOMPA with certain other medicines can cause side effects or reduce either drug’s benefit. These other medicines include: birth control, carbamazepine, phenytoin, oxcarbazepine, rifampin, and St. John’s wort.

Before taking FYCOMPA, patients should tell their healthcare provider if they drink alcohol. Patients should not drink alcohol or take other medicines that make them sleepy or dizzy while taking FYCOMPA until they talk to their healthcare provider. FYCOMPA taken with alcohol or medicines that cause sleepiness or dizziness may make their sleepiness or dizziness worse.

Before taking FYCOMPA, patients should tell their healthcare provider if they are pregnant or plan to become pregnant while taking FYCOMPA. It is not known if FYCOMPA will harm your unborn baby. If a patient becomes pregnant while taking FYCOMPA, they should talk to their healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry (1-888-233-2334).

Before taking FYCOMPA, patients should tell their healthcare provider if they are breastfeeding or plan to breastfeed. Patients should talk to their healthcare provider about the best way to feed their baby if they take FYCOMPA. Patients should not take FYCOMPA if they breastfeed.

Before taking FYCOMPA, patients should tell their healthcare provider if they have liver or kidney problems. They should not take FYCOMPA if they have severe kidney or liver problems.

FYCOMPA is a controlled substance (CIII) because it can be abused or lead to drug dependence. Before taking FYCOMPA, patients should tell their healthcare provider if they have abused prescription medicines, street drugs, or alcohol in the past. Patients should keep their FYCOMPA in a safe place to protect it from theft and should never give it to anyone else because it may harm them. Selling or giving away FYCOMPA is against the law.